June 23 Day 1 – Speaker dinner
June 24 Day 2
9.00 – 9.05 Welcome
9.05 – 9.30 Lori Passmore, Mechanistic insights into the poly(A) tail machinery
9.30 – 9.55 Aaron Goldstrohm, A Goldilocks tale of the poly(A) tail
9.55 – 10.20 Anita Corbett, Regulation of RNA Decay/Processing by Modulating RNA Modifications
10.20 – 10.35 Zbigniew Warkocki, Dissecting human RNA 3′ End Metabolism via Genome-wide Profiling of Uridylation and RNA Decay Pathways
Coffee break
11.05 – 11.30 Sutapa Chakrabarti, Molecular mechanisms of recruitment, function and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay
11.30 – 11.55 Sue Lin-Chao, Allosteric Rewiring: Defining the Direct Regulation of PNPase Activity by an Essential Glycolytic Intermediate in E. coli.
11.55 – 12.10 Hanzhang Yu, Dynamic remodeling of mRNA poly(A) tails during the dark-to-light transition in Arabidopsis seedlings
12.10 – 12.30 Flash talks
Lunch with posters 12.30 – 15.00
15.00 – 15.25 Ambro van Hoof, EXOSC1/Csl4 exosomopathy variants have distinct and overlapping in vivo effects on budding yeast RNA exosome function
15.25 – 15.50 Christopher Lima, Contributions of the RNA exosome to RNA quality control
15.50 – 16.05 Derrick Morton, RNA surveillance as a determinant of neuronal lineage progression and selective vulnerability
Coffee break
16.35 – 17.00 Scarlet Shell, Uncovering new players in mycobacterial RNA processing and degradation
17.00 – 17.25 David Bartel, How microRNAs are targeted for degradation
17.25 – 17.40 Andriana Ntogka, Target-Induced microRNA Stability Promotes Chronic Stress Adaptation and Longevity
Free evening/dinner
June 25 Day 3
9.00 – 9.25 Andrzej Dziembowski, Metabolic pathways of endogenous and therapeutic mRNAs in vivo
9.25 – 9.50 Jörg Vogel, Why an understanding of RNA decay is important to develop new RNA-centric antibiotics
9.50 – 10.15 Julian Stingele, The role of RNA damage in chemotherapy
10.15 – 10.30 Georg Stoecklin, An unexpected role of mRNA turnover in hypertrophic cardiomyopathy driven by a hereditary nonsense mutation in MYBPC3
Coffee break
11.00 – 11.25 Sangjin Kim, Cellular aspects of mRNA degradation in E. coli
11.25 – 11.50 Steven West, Transcriptional quality control by Integrator and Restrictor
11.50 – 12.15 Torben Heick Jensen, Nuclear sorting of RNA
12.15 – 12.30 Yuyang Miao, An mRNA decay feedback mechanism drives mRNA concentration homeostasis as cell size increases in growing cells.
Lunch 12.30 – 14.00
14.00 – 14.25 Ben Luisi, Riboregulation and ribosome response to antibiotic stress in bacteria
14.25 – 14.50 Ciarán Condon, Latest developments in Bacillus subtilis mRNA decay
14.50 – 15.15 Danny Nedialkova, Mechanisms Governing the tRNA Lifecycle
15.15 – 15.30 Agata Starosta, Ribosomes translocation into the spore of Bacillus subtilis
Coffee break
16.00 – 16.25 Frances Diehl, Mechanism of nucleolytic degradation of human ribosomes
16.25 – 16.50 Joshua Mendell, Regulation of translation-coupled mRNA turnover
16.50 – 17.15 Oliver Mühlemann, Translation-dependent mRNA decay pathways
17.15 – 17.30 Ryan Kawalerski, A unique pathway of mRNA decay associated with ribosomal accommodation of aberrant tRNAs
Free evening/dinner
June 26 Day 4
9.00 – 9.25 Britt Glaunsinger, Viral and anti-viral RNA decay drives transcriptional repression
9.25 – 9.50 Chad Swanson, Structural and functional characterisation of the antiviral endoribonuclease KHNYN
9.50 – 10.15 Narry Kim, RNA stabilization strategies across human and viral mRNAs
10.15 – 10.30 Roland Beckman, The license to degrade rRNA in yeast
Coffee break
11.00 – 11.25 Hannah Burgess, Poly(A) tail length manipulation is a conserved viral tactic
11.25 – 11.50 Marta Gaglia, RNA decay as an immune evasion strategy: the selective influenza endonuclease PA-X
11.50 – 12.15 Nicole Marino, Translation-dependent degradation of cas12a mRNA by an anti-CRISPR protein
12.15 – 12.35 Flash talks
Lunch with posters 12.35 – 15.00
15.00 – 15.25 Bobby Hogg, Protein and RNA determinants of NMD kinetics
15.25 – 15.50 Niels Gehring, Molecular Mechanism and Cellular Function of Nonsense-Mediated mRNA Decay
15.50 – 16.15 Joshua Arribere, SMG-5 stimulates SMG-6-mediated cleavage during NMD
16.15 – 16.30 Kristian Baker, Length-Dependent Binding of UPF1 to Neo-UTRs Triggers Nonsense-Mediated mRNA Decay in Yeast
Coffee break
17.00 – 17.15 Matthias Soller, 2`-O-methylation of cap-adjacent nucleotides protects TOP messenger RNA from degradation by DXO
17.15 – 17.40 Jared Shrader, Bacterial Ribonucleoprotein bodies promote mRNA decay and storage across species
17.40 – 18.05 Joel Belasco, Mechanism of RNA scanning by RNase E
Concluding remarks
Conference dinner
19.30 – 20.00 Business meeting and Poster prize